This review provides an overview of how the defensive mucus of the airways functions in health, how the mucus can fail to clear with muco-obstructive lung diseases, how mucins respond to pathogens that infect the mucus, how the molecular signals of mucin secretion function, and how therapeutics may improve morbidity and mortality for people with muco-obstructive lung disease
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Genetics may provide complementary information in the future, but its current clinical utility is limited
Most published studies are small, involve patients affected by obesity and/or T2DM, and may therefore not be fully generalizable to the broader PsO/PsA population